Search results for "cell culture"

Article Adherent Cell Culture in Biopharmaceutical Applications: The Cell-Detachment Challenge
Giner-Casares Cell culture is widely employed in biomedical applications and has numerous applications, spanning from diagnosis, therapy, and the production of biological drugs. Cells used for bio…

Article A Risk-Based Genetic Characterization Strategy for Recombinant CHO Cell Lines Used for Clinical and Commercial Applications
…ose (FHD) or first-in-human (FIH) application, and leveraging a “commercializable” platform for cell culture and downstream process development. At the heart of this strategy is the view that the pro…

Article Changing the Culture of Cell Culture: Applying Best Practices and Authentication to Ensure Scientific Reproducibility
Microbial contamination of continuous cell cultures by a wide variety of microorganisms is also problematic in cell culture laboratories worldwide, particularly by mycoplasma. The latter can be diffic…

Article The Evolving Role of Starting Materials in Cell and Gene Therapy
The Evolving Role of Starting Materials in Cell and Gene Therapy Accelerated approval pathways and growing demand for cell and gene therapies are putting pressure on providers of cellular starting m…

Article Best Practices for Selecting a Top-Quality Cell Line
Irina Shi - Stock.Adobe.com Leveraging automation and a step-by-step approach are keys to success. By Cynthia A. Challener Cell lines determine the performanc…

Article Commercial Production of Gene Therapies Using Suspension or Adherent Cell Lines
and must be produced in cell culture. This is, most often done using transient transfection as a means of integrating the viral genome into the cells, although stable producer cells lines aredeveloped…

Article Mapping a Route for Cell and Gene Therapy Process Development
Looking at cell therapies, Baghbaderani notes that the main differences in scaling allogeneic applications lies in the cellular characteristics, cell culture systems, and unit operations utilized in t…

Article Design Considerations for a Commercial Cell and Gene Therapy Facility
“The scales of processing at the moment top out at about 2000 L of cell culture, which is in line with smaller mAb manufacturing processes,” Ramaswamy states. On the other hand, cell and ex-vivo…

Article Challenges in Cell Harvesting Prompt Enhancements
Challenges in Cell Harvesting Prompt Enhancements Higher cell titers and cell densities have posed a challenge to cell harvesting, a crucial step in biologics manufacturing. By Feliza Mi…

Article Cell-free Expression Systems Pose Cell Culture Alternative
Feliza Mirasol Among the challenges in upstream bioprocessing is the cellular waste generated as a by-product of cell culture. One approach that potentially offers the benefit of a “cleaner”…

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