Search results for "bispecific"
Article
A Look at the Affinity Chromatography Landscape
Affinity chromatography for bispecific antibodies
Due to the molecular diversity of bispecific antibodies, a general purification platform is not available. A toolbox approach is needed, in which …
Article
Advances in Engineering of Protein-Based APIs
Bi/multispecific proteins
Bispecific antibodies are an important emerging area in advancing protein engineering for pharmaceutical products, and several bispecifics based on immunoglobulin scaffol…
Article
Chromatography for the Diversified Antibody Pipeline
The antibodies have been there; however, we have also seen the development of fragments, conjugates, and bispecific antibodies. About 25 percent of the biopharmaceuticals are not pure antibodies they …
Article
Top Tips for Successful Development of Antibody Chromatography Processes
That's where we end up in conversations with clients about how to remove them, but also mispairs or separation of homo/hetero-dimers or bispecific antibodies. So we’ll start with aggregates.
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Article
Best Practices for Selecting a Top-Quality Cell Line
“A balanced plasmid ratio usually has dramatic impact on some formats of bispecific antibody cell line development to minimize impurities,” she explains. Factors such as cell growth and metabolism, as…
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Guide for selecting affinity resins for mAbs, bsAbs, and antibody fragments
Today, molecules such as bispecific antibody (bsAb) and antibody fragments such as Fab, scFv, and VHH are seen in labs all over the world. These target molecules need to be purified to reach required …
Article
As the therapeutic pipeline diversifies, chromatography toolboxes are expanding.
Development beyond traditional monoclonal antibodies (mAbs) is increasing, and today, we see antibody variants like multispecific and bispecific antibodies and antibody fragments. In mAb proc…
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Get to know: mAb variants - eLearning
Key learnings are:
- Structure and binding domains for antibody variants
- Advantages and disadvantages of different antibody fragments
- Design strategies for bispecific antibodies (bsAbs)
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Article
Get Started: Purification of mAb Variants - eLearning
The success of monoclonal antibodies (mAbs) as therapeutics and the multi-domain structure of antibodies has made it possible to create antibody variants, such as bispecific antibodies (bsAbs)…
Article
Chromatography innovations for the diversified antibody pipeline
MabSelect™ VH3 resins provides efficiency in capture of bispecific antibodies and antibody fragments such as Fab, scFv, and VHH. Discover how we’re supporting the diverse antibody pipelines with chrom…