Search results for " yeast" in Articles / App Notes

Article Fermentation for the Future
Jan 01, 2015 By Cynthia Challener, PhD Microorganisms—bacteria and yeast—have been widely used for the production of genetically engineered (recombinant) biopharmaceuticals. Typical examples…

Article Antibody Production in Microbial Hosts
Challenges associated with the production of antibodies in microbial hosts Microbial cells such as yeast and bacteria possess many advantages, such as fast growth, well-known genetics, and low…

Article Addressing the Challenges in Downstream Processing Today and Tomorrow
In addition to high cell density mammalian expression, expanded utilization of other expression systems such as microbial and yeast will support these newer biotherapeutics (BioTx). The diversity of B…

Article Evolution of the Monoclonal Antibody Purification Platform
Monoclonal antibodies expressed in yeast While mammalian cells (e.g., such as Chinese hamster ovary [CHO]), have been the primary expression system for mAb products; other expression systems such …

Article A Closer Look at Affinity Ligands
…bilized 14 kD single variable domain of heavy chain (VHH) antibody that is recombinantly produced in yeast. The single-domain heavy chain antibody fragments from Camelidae have also been utilized suc…

Article Paring Down Impurities in Downstream Processing
Biopharmaceutical expression systems range from yeast and insects to mammals and plants. Bioreactors to house these systems might be stirred-tank, air-lift, fixed-bed, hollow-fiber perfusion, or suspe…

Article Recent Advances in the Use of Exoglycosidases to Improve Structural Profiling of N-glycans from Biologic Drugs
First, recombinant production of all enzymes was achieved in Escherichia coli or yeast hosts. This required discovery of some genes encoding plant enzymes that had never been produced recombinantly (e…

Article The Challenge of Disruptive Technologies in Bioprocessing
… of the ever-increasing biomass from highly productive mammalian cell culture, and even more so with yeast systems,” notes Jagschies. The high cost, or perceived cost, of an established techno…

Article Sanitization of ÄKTA™ pilot 600 Using Sodium Hydroxide
In a microbial challenge test, parts were exposed to a bacterial strain recommended by the United States Pharmacopoeia (USP 38) and to yeast strains commonly used in production environments. Sanitizat…

Article Platform Technologies Improve Protein Expression
Tools enabling modification of metabolic pathways for glycosylation in algae and yeast glycosylation are also noteworthy. “These approaches offer avenues for designing better fit-for-purpose molecules…

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