Search results for " Mab purification"
Article
Modeling the Degradation of mAb Therapeutics
Modeling the Degradation of mAb Therapeutics
Kinetic models can be used to study aggregation and fragmentation to help ensure stability.
By Anurag S. Rathore, Rohit Bansal
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Article
Optimizing Cation-Exchange Chromatography with High-Throughput Process Development for mAb Purification
Case study: Accelerating mAb purification via HTPD
The mAb used in the following case study was produced in Chinese hamster ovary (CHO) cells, and the initial mAb capture step was carried out with a…
Article
Developing a Closed, Connected Single-Use mAb Purification Process
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Learn more on this case study to set up a closed and connected single-use monoclonal antibody (mAb) purification process that addresses a perfusion upstream process. In the Pr…
Article
Speeding Up mAb Purification Using Fiber-based Technology
Read more on high throughput automated mAb purification using HiTrap Fibro PrismA.
Article
Addressing mAb Purification Bottlenecks with Rapid Cycling Chromatography
Fibro chromatography is a recently launched chromatography platform that enables purification cycles in minutes rather than hours. The rapid purification enables higher throughput in research and pr…
Article
Evaluation of Fibro PrismA for Scalable Single-Use mAb Purification
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In clinical monoclonal antibody (mAb) manufacturing, capture on protein A chromatography resin gives excellent recovery and purity. However, because clinical batch siz…
Article
Case Study: High Throughput mAb Purification Using Fibro
In this case study, a drug discovery lab at AstraZeneca finds that purifying antibodies with Fibro PrismA means they can screen more candidates per week with a simpler equipment setup.
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Article
Technical and Process Economical Aspects of Using Capto™ Q and ReadyToProcess™Adsorber Q in mAb Polishing
… packed in conventional chromatography columns when used in the final polishing step of a three-step mAb purification process. To identify scenarios for beneficial use of each of these product altern…
Poster
Modes of controlling charge variant distribution in Mab production
The characteristics of a biological drug, for example, charge variant profile, are determined to a large extent by the upstream expression system and conditions, but can also be influenced by the pu…
Article
Strategies and Emerging Technologies for mAb Capture
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In this webinar, we will describe and evaluate different process intensification strategies for the monoclonal antibody (mAb) capture step. Strategies wi…