Search results for " Mab purification"
Article
Modeling the Degradation of mAb Therapeutics
Modeling the Degradation of mAb Therapeutics
Kinetic models can be used to study aggregation and fragmentation to help ensure stability.
By Anurag S. Rathore, Rohit Bansal
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Article
Optimizing Cation-Exchange Chromatography with High-Throughput Process Development for mAb Purification
Case study: Accelerating mAb purification via HTPD
The mAb used in the following case study was produced in Chinese hamster ovary (CHO) cells, and the initial mAb capture step was carried out with a…
Article
Developing a mAb aggregate removal step by high throughput process development
This case study illustrates the benefits of using the HTPD approach for choice of media and optimization of the polishing step in a two-step MAb purification process. The use of a 96-well plate format…
Article
Faster scale-up of a two-step MAb process with AxiChrom™ columns and ReadyToProcess™ solutions
Abstract
Transferring optimized purification development results to pilot- and full-process scale is a key component for successful MAb production. Scale-up needs to be robust, predictable, and …
Article
Rapid process development for the purification of a MAb using ÄKTA™ avant 25
Therefore, protein A-based media are the basis for the platform approach to MAb purification.
Subsequent downstream processing can be performed according to a variety of chromatography techniques…
Article
High-throughput screening methods to speed MAb process development
Introduction
As clinical applications of monoclonal antibodies continue to engage the healthcare community, biopharmaceutical manufacturers are striving to make products available as quickly and…
Tip
A Polished Performance in MAb Purification
Multimodal chromatography media (resin), e.g., the new Capto™ adhere ImpRes, has been proven very successful in the polishing steps of monoclonal antibodies (MAbs). Selection of buffer compositi…
Article
Speeding Up mAb Purification Using Fiber-based Technology
Read more on high throughput automated mAb purification using HiTrap Fibro PrismA.
Article
Addressing mAb Purification Bottlenecks with Rapid Cycling Chromatography
Fibro chromatography is a recently launched chromatography platform that enables purification cycles in minutes rather than hours. The rapid purification enables higher throughput in research and pr…
Poster
Designing a continuous three-step MAb purification process
New emerging technologies such as periodic counter-current chromatography (PCC) and straight-through processing (STP) are entering the market. Here, these two technologies were evaluated in a contin…