Search results for "multimodal"

Article Multimodal Chromatography Handbook
Because of the broad applicability and the new selectivity that the multimodal media bring, they are adopted throughout the biopharmaceutical industry. In this most recent handbook from GE Healthc…

Poster Mab polishing using a new multimodal anion exchanger
To address theses challenges, a new multimodal anion exchange medium with a particle size designed for polishing (40 mm) was developed. The new medium, Capto™ adhere ImpRes, displays high resolution, …

Article High-throughput screening and optimization of a multimodal polishing step in a monoclonal antibody purification process
The complexity of multimodal media requires a more thorough process optimization study in order to take full advantage of the outstanding potential of this technology. This calls for the development…

Poster Evaluation of different cation multimodal ligand structures for capture of pro-insulin
In this investigation 15 different cation multimodal ligands containing different hydrophobic and anionic groups were evaluated. The evaluation was performed using a High Throughput Process Developmen…

Poster Multimodal chromatography media to resolve purification platform challenges of ‘tricky’ MAbs
Monoclonal antibodies (Mabs) are commonly purified using platform approaches, where the initial protein A capture step is followed by two polishing steps. Protein A capture is a generic step that do…

Tip How to elute proteins from multimodal chromatography resins, like Capto™ MMC and Capto adhere
Mixed mode ion exchangers frequently exhibit useful selectivity that can be exploited to achieve purification in fewer steps. Frequently, both a pH change and an increase in salt concentration are r…

Article Developing a mAb aggregate removal step by high throughput process development
In the polishing step of a two-step process, a multimodal chromatography medium capable of several interactions (e.g., hydrophobic, ion-exchange interactions, hydrogen bonding) can be used, which allo…

Article Mixed-Mode Chromatography in Downstream Process Development
By Felix Oehme, PhD, and Joerg Peters, PhD ABSTRACT Mixed-mode chromatography materials contain ligands of multimodal functionality that allow protein adsorption by a combination of ionic interac…

Article Improving Process-Scale Chromatography
Alternatives to Protein A chromatography are available based on techniques such as precipitation, ion exchangers, and multimodals/mimetics. “It is challenging to compete on selectivity with the years …

Article A Q&A With Prof. Alois Jungbauer: The Role of HIC in Biotech
Maybe it was not as advantageous as first indicated? At the conference there were presentations on multimodal chromatography. How do you value multimodal chromatography compared to HIC? Multim…

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