Search results for "Mab"

Article Modeling the Degradation of mAb Therapeutics
This is particularly true for monoclonal antibodies (mAbs), which account for most commercial biopharmaceuticals today. Both physical effects such as aggregation and chemical modifications (e.g., frag…

Article Optimizing Cation-Exchange Chromatography with High-Throughput Process Development for mAb Purification
…velopment of robust, efficient, and economic purification strategies for new monoclonal antibodies (mAbs) coming through the pipeline. Since the first therapeutic antibody came onto the market in 198…

Article mAbs to Watch in 2016
mAbs in development Most of the products listed below are in Phase III trials; however, a few are in earlier stages of development. Although the pharmaceutical manufacturers developing these mAbs w…

Article Developing a mAb aggregate removal step by high throughput process development
This initiative also is applicable to the development of downstream processes in the manufacture of monoclonal antibodies (MAbs). In this area, a new approach of high throughput process development (H…

Article Impact of Manufacturing-Scale Freeze-Thaw Conditions on a mAb Solution
…thaw conditions on aggregation and subvisible particle formation of a monoclonal antibody solution (mAb-A; IgG1) using a small-scale model. The temperature-time profiles of manufacturing-scale sample…

Article Faster scale-up of a two-step MAb process with AxiChrom™ columns and ReadyToProcess™ solutions
The addition of readyto-use solutions to the upstream/downstream process significantly shortens the time-to-clinic journey for MAbs. Scaling up with AxiChrom columns In the scale-up describe…

Article Rapid process development for the purification of a MAb using ÄKTA™ avant 25
MabSelect SuRe™, a protein A-based chromatography medium (resin) was used for the initial capture step while the multimodal anion exchanger Capto™ adhere was used for reduction of impurities in a seco…

Tip A Polished Performance in MAb Purification
However, MAbs may leak from the column during washes and/or early in the gradient. If MAb is eluting during the wash step, you could use buffer with lower conductivity and/or avoid buffer blending’s i…

Poster Modes of controlling charge variant distribution in Mab production
Charge variant distribution is a critical quality attribute for MAbs and is therefore of interest to monitor and control during the production process. In this study, we investigated the effects of ce…

Poster Multimodal chromatography media to resolve purification platform challenges of ‘tricky’ MAbs
Designing a robust polishing step, however, requires process optimization, in which it is crucial to also consider MAb stability. This poster describes the screening and optimization of conditions for…

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