Search results for "Mab"

Article Modeling the Degradation of mAb Therapeutics
This is particularly true for monoclonal antibodies (mAbs), which account for most commercial biopharmaceuticals today. Both physical effects such as aggregation and chemical modifications (e.g., frag…

Article Optimizing Cation-Exchange Chromatography with High-Throughput Process Development for mAb Purification
…velopment of robust, efficient, and economic purification strategies for new monoclonal antibodies (mAbs) coming through the pipeline. Since the first therapeutic antibody came onto the market in 198…

Article mAbs to Watch in 2016
mAbs in development Most of the products listed below are in Phase III trials; however, a few are in earlier stages of development. Although the pharmaceutical manufacturers developing these mAbs …

Article Impact of Manufacturing-Scale Freeze-Thaw Conditions on a mAb Solution
…thaw conditions on aggregation and subvisible particle formation of a monoclonal antibody solution (mAb-A; IgG1) using a small-scale model. The temperature-time profiles of manufacturing-scale sample…

Article Improving mAb Manufacturing Productivity by Optimizing Buffer and Media Prep Process Flow
A typical monoclonal antibody (mAb) process may require 2000 L of a buffer and more than 100,000 L per batch based on titer and bioreactor volume (1, 2). As a result, the variety of buffer solutions u…

Poster Modes of controlling charge variant distribution in Mab production
Charge variant distribution is a critical quality attribute for MAbs and is therefore of interest to monitor and control during the production process. In this study, we investigated the effects of ce…

Article Evaluation of Fibro PrismA for Scalable Single-Use mAb Purification
Bayer worked with Cytiva to evaluate a fiber-based alternative, Fibro PrismA, to determine its potential as a truly single-use mAb capture technology. The team assessed scalability from lab- to proces…

Article Strategies and Emerging Technologies for mAb Capture
In this webinar you will learn: • Strategies and emerging technologies for intensifying the mAb capture step • How the design of your upstream mode may determine your optimal downstream soluti…

Article Integrated Semi-Continuous Process for mAb Production
In brief, the mAb process consists of perfusion cell culture, continuous capture chromatography, viral inactivation (VI), post VI filtration, batch polishing chromatography, and a final pH adjustment …

Article Assessing leachables risk over a complete single-use, mAb process
In an article, process equipment-related leachables are mapped over a complete single-use mAb process at pilot scale. READ FULL ARTICLE >>

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