Search results for "bispecific antibody"

Article Witnessing Major Growth in Next-Generation Antibodies
MacroGenics’ dual-affinity re-targeting (DART) technology, which can target multiple disease-causing cells or different disease-causing pathways with one antibody, is also a bispecific antibody approa…

Article Applications of Surface Plasmon Resonance for Detection of Bispecific Antibody Activity
FDA has approved a bispecific antibody—Amgen’s Blincyto (blinatumomab)—for the treatment of refractory B-cell precursor acute lymphoblastic leukemia (ALL). Blincyto targets cell surface proteins CD19 …

Article Single-Domain Antibodies for Brain Targeting
Single-domain antibodies are emerging as credible alternatives due to their target specificity, high affinity, and cost-effective recombinant production. Smaller recombinant antibody fragments a…

Article Single-Step, Protein A Chromatography Process for Bispecific Antibodies in Early Screening
A single-step downstream process using protein A chromatography to purify a bispecific antibody (BsAb) in early screening has been successfully developed to replace an existing three-step process. T…

Article Bispecific Antibody Purification: Insights and Case Studies
New modalities, like bispecific antibodies, present unique challenges compared to mAb production. For purification, there’s not just one right answer to which strategy to use. Here are some industry…

Poster Single-Step, Protein A Chromatography Process for Bispecific Antibodies in Early Screening
A single‑step downstream process using protein A chromatography to purify a bispecific antibody (BsAb) in early screening has been successfully developed to replace an existing‑three step proces…

Poster Development of a Purification Platform Process For a Unique Next-Gen Antibody
 NovImmune's novel bispecific antibody format, the κλ-body, has a molecular structure similar to standard monoclonal antobodies.  This poster addresses challenges designing a platform purification pro…

Article A Look at the Affinity Chromatography Landscape
In addition, resins with affinity for many VH3 domain regions are often a good choice for bispecific antibody fragments, while resins with affinity for the kappa light chain may be better alternatives…

Article Advances in Engineering of Protein-Based APIs
Advances in Engineering of Protein-Based APIs New platform technologies, advanced modeling tools, and addressing patient needs are important developments. By Cynthia A. Challener …

Article Process Development: What May Lie Ahead in 2018?
2018 is shaping up to be an interesting year in the world of biopharmaceuticals. What have 2017 developments taught us, and what may lie ahead for biopharmaceutical drug developers and process engin…

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