Search results for "bispecific antibody"

Article Witnessing Major Growth in Next-Generation Antibodies
MacroGenics’ dual-affinity re-targeting (DART) technology, which can target multiple disease-causing cells or different disease-causing pathways with one antibody, is also a bispecific antibody approa…

Article Applications of Surface Plasmon Resonance for Detection of Bispecific Antibody Activity
FDA has approved a bispecific antibody—Amgen’s Blincyto (blinatumomab)—for the treatment of refractory B-cell precursor acute lymphoblastic leukemia (ALL). Blincyto targets cell surface proteins CD19 …

Article Single-Domain Antibodies for Brain Targeting
Single-domain antibodies are emerging as credible alternatives due to their target specificity, high affinity, and cost-effective recombinant production. Smaller recombinant antibody fragments a…

Article FDA Provides Guidance on Bispecific Antibody Development Programs
“This guidance focuses on a range of regulatory and scientific considerations for bispecific antibodies, but not on development of a particular bispecific antibody. Of note, many aspects of a bispecif…

Article Single-Step, Protein A Chromatography Process for Bispecific Antibodies in Early Screening
A single-step downstream process using protein A chromatography to purify a bispecific antibody (BsAb) in early screening has been successfully developed to replace an existing three-step process. T…

Article Optimization of a Two-Step Purification Method for Bispecific Antibodies
Alligator and Cytiva developed an efficient downstream purification process for a cancer immunotherapy bispecific antibody (bsAb).  Read more

Article Bispecific Antibody Purification: Insights and Case Studies
New modalities, like bispecific antibodies, present unique challenges compared to mAb production. For purification, there’s not just one right answer to which strategy to use. Here are some industry…

Article Platform for Purification of VHH-type Antibody Fragments
Click here to read this poster >> Protein A affinity chromatography resins have been used to purify monoclonal antibodies (mAbs) by the bioprocess industry at all scales for a long time. Howev…

Article Antibody Production Workflow
Explore the workflow here >> Antibody-based therapies have evolved beyond monoclonal antibodies (mAbs) to include bispecific antibodies, antibody fragments, antibody-drug conjugates (ADCs), and m…

Article Advancements in Antibody Purification
Learn more and register here >>  The demand for more efficient and agile downstream purification processes for diversified therapeutic antibody pipelines requires the development of new…

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