Search results for " resin"

Article Re-use of Protein A Resin: Fouling and Economics
The most significant contributor to the total cost is the Protein A resin. The cost of Protein A resin is nearly 50% higher than traditional chromatographic media with nonproteinaceous ligands (2, 10)…

Article Comparing Protein A Resins for Monoclonal Antibody Purification
As a consequence, downstream processing must accept and handle higher titers of mAbs in harvested cell-culture fluid (HCCF), and vendors of mAb purification technologies must develop chromatography re…

Article Optimizing Resin Performance with Disposable Chromatography Solutions
The experts addressed how disposable chromatography columns can be used throughout the life of a campaign, the costs and benefits associated with using prepacked columns, the complexities of resin str…

Article Development and Future of Protein A Chromatography Technology: Q&A with Jonathan Royce, Business Leader Chromatography Resins, GE Healthcare
Although Protein A resins introduced to the market in the last 10 years withstand low to medium concentrations of sodium hydroxide for cleaning, like 0.1 M sodium hydroxide and in some cases 0.5 M, th…

Poster Evaluation of Protein A resin lifetime during extensive use (overloading) in continuous chromatography mode
This application note compares the performance of MabSelect SuRe pcc resin designed for continuous capture of mAbs, with the conventional high-capacity Protein A resin MabSelect SuRe LX. The study was…

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Article Increasing Productivity in Hydrophobic Interaction Chromatography (HIC) Using Capto™ Resins
An application example is also presented in which aggregate removal results are compared using Capto™ Butyl ImpRes and Butyl Sepharose High Performance resins. Download the application note >>

Poster Process Economy Impact of Protein A Resin Alkaline Stability
This poster presents a process economy simulation comparing three protein A chromatography resins with the aim to demonstrate the influence of dynamic binding capacity (DBC) and alkaline-stability of …

Article Cleaning Protein A Resins with 1 M NaOH
If not removed, these impurities can build up on the protein A resin and start to leach into the process material in subsequent cycles. The presence of cell culture nutrients in the harvest feed loade…

Article Capacity and Performance of a Next Generation Protein A Chromatography Resin
The resin exhibits improved capacity over its predecessor MabSelect SuRe™ products, while maintaining purification performance. This application note demonstrates the binding capacity and purification…

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