Search results for " monoclonal antibody"

Article Witnessing Major Growth in Next-Generation Antibodies
Real advantages These new antibody formats are attracting attention because they have several advantages over current monoclonal antibody therapies. “These new modalities very often can be more ta…

Article Antibody Production in Microbial Hosts
Structure of a monoclonal antibody and its derivatives Antibodies are glycoproteins consisting of two heavy chains and two light chains that are linked with disulfide bonds. This Y-shaped molecu…

Article Applications of Surface Plasmon Resonance for Detection of Bispecific Antibody Activity
Surface plasmon resonance is helping define bispecific antibodies, the next-generation of biopharma therapeutics. By Robert Karlsson Abstract Biotherapeutic antibodies are still the larg…

Article HT Multi-Product Liquid Chromatography for Characterization of Monoclonal Antibodies
Points to consider in the manufacture and testing of monoclonal antibody products for human use. Rockville, MD; 1997. 5. Schnerman MA, Sunday BR, Kozlowski S, Webber K, Gazzano-Santoro H, Mire-Slu…

Article Single-Domain Antibodies for Brain Targeting
Single-domain antibodies are emerging as credible alternatives due to their target specificity, high affinity, and cost-effective recombinant production. Smaller recombinant antibody fragments a…

Article Generating a Fully Processed Antibody
The authors outline cell-line development and process scale-up for an antibody program in which the antibody requires additional processing by a site-specific enzyme for correct functionality. B…

Article The Development and Application of a Monoclonal Antibody Purification Platform
A purification scheme to maximize the efficiency of the purification process and product purity while minimizing the development time for early-phase therapeutic antibodies. The following ar…

Article Defining Critical Quality Attributes for Monoclonal Antibody Therapeutic Products
Figure 1: The total ion current (TIC) chromatogram obtained from on-line reverse phase-high-performance liquid chromatography with electrospray mass spectrometry (RP-HPLC/ES-MS) analysis of a monoclon…

Article Comparing Protein A Resins for Monoclonal Antibody Purification
With greater economic pressure on monoclonal antibody (mAb) production for therapeutic and research uses, antibody titers in mammalian cell culture have increased dramatically over the past 20 years. …

Article Evolution of the Monoclonal Antibody Purification Platform
Traditional Monoclonal Antibody Platform Figure 1 illustrates the traditional mAb platform that is commonly used (2,3). Typical steps include: • Protein A chromatography for capture of…

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