January 26, 2024

A scalable single-use two-step plasmid purification process

The current global demand for biopharmaceuticals is over USD 300 billion, with an estimated growth of ≥ 12% annually. While MAb processes have become much more efficient, production of mRNA and viral vectors is still hindered by the requirement for a reliable source of high-quality plasmid DNA (pDNA), which typically requires multiple purification steps to achieve.

Tags: capture, chromatography, gene therapy, purification, Pdna