Search results for " fed-batch"
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Maximizing the Effectiveness of Upstream Bioprocessing Through the Combination of Lab Informatics and Instrumentation
…roductivity with their WuXiUP continuous perfusion-based processing platform compared to traditional fed-batch, which enables 1000-L single-use bioreactors to produce the same amount as 10,000-L stai…
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Cell-Culture Advances Test Bioreactor Performance Models
He points to the higher cell densities in perfusion mode, which result in increased oxygen demand in a higher viscosity solution with potentially more cell-free biopolymers and lipids than a fed-batch…
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Scaling Up Novel Therapies
One way they do this, he says, is by “scaling out,” intensifying processes, for example by using fed-batch and perfusion on the upstream side, and multicolumn operations, whether it’s just higher cycl…
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Impact of Media Components on CQAs of Monoclonal Antibodies
CHO cells in fed-batch mode at low glutamine (17% (w/w) hampered the rate of deamidation up to 40%. Polyols at high concentrations displayed a protective effect on oxidation. Addition of 0.01% (v/v) P…
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A Small-Scale Model to Increase Yield in Cell Culture Perfusion of mAb at Large Scale
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As process intensification is adopted into large-scale manufacturing, the responsibility on scale-down models to accurately represent the expanded operating space quickly follow…
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Explore the Process Intensifier App
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How do you know if an intensification approach will give you advantages over your current biomanufacturing process, and how do you choose the …
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The Importance of Process Intensification and PAT for Achieving Real-Time Release
As the industry has matured, effective manufacturing platforms and analytical tools and technologies appropriate for fed-batch manufacturing in stainless-steel or single-use bioreactors have also adva…
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Developing a Continuous Large-Scale Perfusion Cell Culture Process
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Perfusion processes enable continuous operation over extended periods of time by constantly providing fresh nutrients for the cells and simultaneously removing spent…
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Developing a Continuous Large-Scale Prefusion Cell Culture Process
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Perfusion processes enable continuous operation over extended periods of time by constantly providing fresh nutrients for the cells and simultaneously removing …
Article
Improving Upstream Predictability
“We’ve consistently been seeing titers in the range of 4–6 g/L in [monoclonal antibody] mAb fed-batch processing within a chemically defined media environment. This environment, in turn, results in mo…