Search results for " inline"
Poster
Scaling In-Line Buffer Preparation from Process Development to Manufacturing
Preparing buffers for large-scale chromatography requires significant resources: time, money, and storage space. Inline conditioning (IC) is one possible way to address these challenges. At the same t…
Article
Optimizing Late-Stage and Commercial Cell-Culture Processes
There is also an increasing emphasis on inline monitoring of nutrients/metabolites and at-line monitoring of product quality attributes, adds Dr. Rajesh Beri, technical director biomanufacturing, Lonz…
Article
Driving Change in Biomanufacturing
Whatever the objective, driving change is a challenge. Implementing a new technology into a bioprocess is a big change. The new technology must be fully understood, all regulatory requirements fulfi…
Article
Automated In-Line Buffer Preparation from Ready-Made Stock Solutions in a mAb Process Step
To further reduce the time and space required, ready-made stock solutions delivered in disposable bags were connected directly to the Inline Conditioning system and feedback regulation of the final bu…
Article
Overcoming Buffer Challenges With In-Line Conditioning
Preparation and storage of the large number of buffers required for biopharmaceutical production can be a challenge, particularly in large production scale. In this application note, we show how in-…
Article
Use of Multivariate Data Analysis in Bioprocessing
Another group employed unsupervised PCA and PLS to analyze data from inline Fourier Transform-near-infrared (FT-NIR) spectroscopy of a mammalian cell culture process for identification of batch homoge…
Article
Improving PAT for Biologics
…, pH, dissolved oxygen, conductivity, flow rate, and basic molecular percentages, PAT has shifted to inline/online methods including the determination of cell, nutrient, and metabolite concentrations…
Article
Trends in Downstream Bioprocessing
These include, among many other new technology approaches identified in the study, the development of:
• Higher capacity resins
• Use of inline buffer dilution
• Use of inline conditioning…
Article
Digitalization: The Route to Biopharma 4.0
For dynamic inline pH adjustment in continuous processing, model-based control strategy has been employed by predicting the pH profile between the chromatography wash and the elution steps, thereby fa…
Article
Top Process Development Trends for 2022 and a Look into 2023
Also, this interview shares insights related to moving from manual buffer preparation to implementing inline conditioning for automated buffer management.
A Smarter, More Digital Future
Invest…