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Poster
A Scalable Adenovirus Production Process
To meet these needs, a process for adenovirus production, from upstream cell culture to downstream purification, using modern tools and technologies was developed.
The novel process is easily sc…
Poster
Process economy and production capacity using single-use versus stainless steel fermentation equipment
Economy simulations were based on an E. coli Dab process. Production scenarios in both single- and multi-product facilities were considered. In comparison with a stainless steel strategy, this study s…
Poster
Impact of sporicidal agent on MabSelect SuRe™ protein A resin lifetime
Hence, there is an interest in evaluating oxidizing agents with sporicidal activities, such as peracetic acid (PAA), in the control of such contaminants.
However, many of the protein-based chromat…
Poster
High-Throughput Downstream Processing Using Cellulose Fiber Chromatography and ÄKTA™ Chromatography Systems
Many analyses require purified proteins, and often substantial hands-on time is required for purification. The novel cellulose fiber technology (known as Fibro) may be used with ÄKTA chromatograp…
Poster
Case Study: Improve Process Economy by Cycling of Prepacked Chromatography Columns
The challenge, however, of using disposable technologies relates to the often higher consumables and operating cost as compared with stainless steel solutions. As projects are scaling up to manufact…
Poster
Perfusion Media Development for Scalable Processes
The nutrient-rich but balanced media should be designed to support very low cell-specific perfusion rates (CSPR) that minimize media consumption while maximizing viable cell days and productivities. O…
Poster
Integration of continuous upstream and downstream operations in mAb production
For a competitive production process, continuous or semi-continuous upstream and downstream processing can be employed. Compared with a process performed in batch runs, continuous processing allows fo…
Poster
Collaborating to address the bioburden challenge
At a minimum, bioburden contaminations lead to reduced productivity as a result of lost batches and/or deviation investigations. Striving towards a bioburden-free process, biopharmaceutical companies …
Poster
Columns up to 1600 mm in diameter packed with protein A chromatography medium using axial mechanical compression
Different methods have been developed to pack a broad range of chromatography media (resins) in columns with axial mechanical compression. This includes packing of traditional BioProcess™ media, such …
Poster
Comparison of Three Different Screening Techniques for Predicting Step Elution Conditions for a Cation Exchanger
It is important that the screening can give an indication of the optimal conditions for binding and/or elution in a chromatographic column run. The aim of this study was to investigate conditions for …