Search results for " bioreactors"
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Single-Use Technologies Prove Effective for Viral Vector Process Development
The single-use systems most used, according to Chor Sing Tan, strategy manager at Cytiva, include T-flasks, roller bottles, cell factories or cell stacks, rocking bioreactors, fixed-bed culture system…
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Tools for Continuous Bioprocessing Development
• Bioreactors themselves, which control this large number of parameters, are large, complex to operate, and have not been standardized.
• Standardization is hampered by use of various platforms and…
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A Plastic Pipeline for Commercial Bioprocessing?
“Single-use bioreactors, currently available in sizes up to 2000–4000 L, are a potential solution when looking for smaller vessel capacities,” says Joe Prado, director, cGMP biomanufacturing operation…
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Improving Upstream Predictability
Used with high cell density cryopreservation, perfusion in N-1 and N-2 bioreactors can reduce the cost of goods by 13.5%, shortening run times and increasing production bioreactor titers, he says.
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Commercial Production of Gene Therapies Using Suspension or Adherent Cell Lines
… offering the advantage of being scalable and readily industrializable using well known stirred tank bioreactors (STRs), as opposed to multi-tray culture systems. To reduce upfront expenses and to ov…
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What’s New in Upstream Technologies
Single-use sensor and adapter
Emerson’s Rosemount 550pH sensor and Rosemount 550DW dissolved oxygen (DO) sensor adapter provide improved sensor stability for single-use bioreactors and are suited …
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Maximizing the Effectiveness of Upstream Bioprocessing Through the Combination of Lab Informatics and Instrumentation
Continuous processing techniques are another factor contributing to the popularity of smaller, single-use bioreactors. Although the industry as a whole has been slow to adopt these techniques, FDA act…
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The New World of Biopharmaceutical Manufacturing
Heintz (Solvay): The evolution of single-use containers from several decades ago to today’s gamma irradiation-stable bioreactors has been one of the most significant transformations; it was the impetu…
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Design Considerations for a Commercial Cell and Gene Therapy Facility
For mAb bioprocessing and viral-vector manufacturing, the equipment needed is similar, such as single-use bioreactors and standard harvest and downstream systems for clarification, tangential flow fil…
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Concentrating Feed—an Applicable Approach to Improve Antibody Production
Fed-batch studies in shake flasks and bioreactors. Fed-batch studies in shake flasks were carried out in 250-mL Erlenmeyer flasks in incubators at 36.5 oC with 5% CO2. Applikon 7-L benchtop bioreactor…