Search results for " bioreactors"
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Bioprocessing Advances in Vaccine Manufacture
This increase included 78% of those surveyed reporting current use of SUS bioreactors and 92% using SUS filter cartridges at some level in bioprocessing (see Figure 1).
SUS have m…
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Mapping a Route for Cell and Gene Therapy Process Development
The biggest challenge, according to Baghbaderani, is the development of large-scale manufacturing processes using 3D computer-controlled suspension bioreactors with appropriate downstream processes. “…
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Scaling Up Novel Therapies
Bioreactor scale-up
In more traditional biopharmaceutical development, bioreactors are typically the most difficult pieces of equipment to scale up, says Fredrik Lundström, product manager for…
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Platform Approach Speeds Process Development
Next, a variable number of cultivation parameter screening and optimization studies are performed in controlled bench-scale bioreactors including DoE approaches. Process fixation and process consolida…
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Implications of Cell Culture Conditions on Protein Glycosylation
Optimum cell-culture development is achieved by working with bioreactors to enhance growth and productivity via selection of basal media and culture feeds and the timing for these feeds; optimizing bi…
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Continuous Manufacturing: A Changing Processing Paradigm
“Currently, only a minority of bioreactors are specified with perfusion capability; however, there is a clear awareness that new facilities must be flexible and adaptable to perfusion technology,” ass…
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QbD and PAT in Upstream and Downstream Processing
To gain perspective on the implementation of quality by design (QbD) and process analytical technology (PAT) in biopharmaceutical processing, BioPharm International spoke with Clinton Weber, as…
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Maximum Output Starts with Optimized Upstream Processing
She points to the mAb sector where stainless-steel bioreactors with tens of thousands of liters of capacity were commonly used for cell culture, but today have been replaced with single-use (SU) biore…
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Biomanufacturing: Demand for Continuous Bioprocessing Increasing
Of the nearly 20 technologies identified, the top technologies this year included single-use bioreactors (noted by 45.9% of respondents), followed by cell culture media including optimization, and the…
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Unifying Continuous Biomanufacturing Operations
“For continuous virus production, multi-stage bioreactors are needed, with configurations that can be either cascades of continuous stirred-tank bioreactors (CSTRs) or CSTRs followed by tubular reacto…