Search results for " yield"
Article
Digitalization: The Route to Biopharma 4.0
In two-column capture chromatography, dynamic control can be obtained using adaptive model-based control strategy that led to process yield of more than 85%. The data from high performance liquid chro…
Article
Report from the 12th Plasma Product Biotechnology Forum
The model output was a prediction of yield and purification rate, and the input included feed flowrate, conductivity, column loading, and total protein concentration. One of the conclusions from the s…
Article
Remote Monitoring and Big Data Advance Upstream Automation
Hybrid models have also been used for predicting yields and endpoints with the integration of optimization algorithms for model predictive control in APC strategies,” he comments.
Such innovations…
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Mapping a Route for Cell and Gene Therapy Process Development
Statistically relevant measurements must be repeated many times to improve process yields and reduce manufacturing cost, which adds cost and time to the development process,” Lamproye observes. He poi…
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Getting a Handle on Biopharma’s Most Critical Quality Attributes and Quality Control
So far, however, research has found that full-out production mode offers a better business case for embracing RTR, as does the potential for using a validated approach for another new product if yield…
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Leveraging Computational Models of Glycosylation for Biopharma QA
During cell culture, even subtle variations in nutrient availability, dissolved oxygen, temperature, ammonia, and pH may impact the intracellular process of glycosylation (1,3) and yield product that …
Article
Real-Time Characterization of Biotherapeutics and Comparability of Biosimilars
Biosimilar two exhibited comparable affinity for binding to FcγRIIIa with respect to Ristova, but others yielded lower values.
Case study: II Binding kinetics of GCS-F biosimilars a…
Article
Single-Step, Protein A Chromatography Process for Bispecific Antibodies in Early Screening
The goal was to separate BsAb monomer from fragments such as the individual heavy and light chain pairs while achieving high purity and yield of BsAb. MabSelect™ PrismA protein A resin was selected fo…
Article
Scaling Up Novel Therapies
For some cell therapies, the current process yield is only 30%, says Morris.
In internal testing, Pall scientists optimized process intensification to make 100 g/d of one product, enough…
Article
State of the Biopharmaceutical Industry: Lessons from 2018 Survey Data
…am processing more flexible and cost-effective, but still generally not speedier or with much higher yields.
3) Manufacturing capacity, including commercial manufacturing, is in a “good place.” B…