Search results for " serum" in Articles / App Notes

Article Single-Domain Antibodies for Brain Targeting
IgG, the main serum antibody, the intact form of which is almost exclusively used in therapeutic antibodies, is a Y-shaped, multidomain protein with antigen-binding sites located on the two Fab (antig…

Article An Integrated Approach to Ensure the Viral Safety of Biotherapeutics
Although several serum-free and chemically defined nutrient media formulations are available for commercial use, many cell-culture applications require use of nutrient media supplementation with serum

Article Ensuring the Biological Integrity of Raw Materials
For example, bovine serum can be contaminated with reovirus, epizootic hemorrhagic disease virus, Cache valley virus, or Vesivirus 2117. Porcine circovirus is sometimes found in porcine trypsin. Minut…

Article Safety Drives Innovation in Animal-Component-Free Cell-Culture Media Technology
Background The development of serum-free mammalian cell-culture media technology has been impressive during the past few decades. The advances can perhaps best be appreciated when compared directl…

Article Ensuring Viral Safety of Viral Vaccines and Vectors
Unscreened human or animal-derived products, such as bovine serum, are now known as potential sources of bovine virus contamination (1). Since then, better safety measures and the use of establ…

Article Single-Use Technologies Prove Effective for Viral Vector Process Development
The presence of serum, culture harvest viability, turbidity, cell lysis reagents, contaminant DNA levels, and residual transfection agents are all upstream factors. Overall process scalability and rob…

Article The Importance of Partnering for Bioanalytical Studies
Intravenous administration of the therapeutic may require a less sensitive assay in your serum samples, whereas an ocular injection of the therapeutic will require a very sensitive serum PK assay to m…

Article Antibody Production in Microbial Hosts
… fastest-growing class of approved therapeutic proteins because of their high specificity, increased serum half-life, and low toxicity (2). These products have been used in biosensors, protein purifi…

Article Ligand-Binding Assays and the Determination of Biosimilarity
The latter would include both assessment of the function of the drug in the serum, as well as the activity of potentially induced host neutralizing anti-drug antibodies (nAbs). “Very importantly, for …

Article HyClone Characterized FBS – Origin Equivalence Study
READ FULL ARTICLE >> Fetal bovine serum (FBS) is still used in many cell culture applications, including viral vector production. FBS from a single origin may be limited, so qualifying FBS from …

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