Search results for "filtration"
Article
The Challenge of Disruptive Technologies in Bioprocessing
A salt-tolerant resin can be beneficial to a purification process by decreasing the need for dilution or eliminating tangential flow filtration steps all together. In addition, there has been increase…
Article
Bioburden Control in the Biopharmaceutical Industry
Field, “Bioburden Control at the Sterile Filtration Step: A Risk-Based Approach,” presentation to European Biopharmaceutical Enterprises (May 2013).
10. Critical Process Filtration Inc., “Partic…
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The New World of Biopharmaceutical Manufacturing
Single-use sensors have been developed for a variety of process parameters for downstream steps such as chromatography, tangential flow filtration, direct filtration, and fill/finish, as well as for s…
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Unifying Continuous Biomanufacturing Operations
In terms of cell retention devices, alternating tangential filtration (ATF) allowed a significant technological step ahead compared with tangential-flow filtration (TFF), comments Morbidelli, although…
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Cost Considerations Drive Lean Technology in Biopharmaceutical Manufacturing
Disposable, single-use filtration is an alternative to outdated centrifugation methods that are difficult to scale and complicated to use. Expanded-bed absorption (EBA) offers an alternative to oversi…
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Ensuring the Biological Integrity of Raw Materials
(1)
Standard procedures for inactivation of adventitious agents include the use of heat, filtration, pH, and gamma irradiation. Thorough cleaning of equipment, testing, and review of material sour…
Article
Selection Guide Size Exclusion Chromatography Columns and Media
Size exclusion chromatography (SEC), also called Gel filtration (GF), separates molecules on the basis of differences in size as they pass through a SEC medium packed in a column. A variety of media…
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Going Small to Achieve Success on the Commercial Scale
Scale-down models are used in the development of nearly every unit operation in the overall biopharmaceutical manufacturing process, including both upstream and downstream steps, and separation and fi…
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Automated harvesting and 2-step purification of unclarified mammalian cell-culture broths containing antibodies
The system consists of two bench-top chromatography instruments connected to a central unit with eight disposable filtration devices used for loading and filtering the cell cultures. The staggered par…
Article
Aseptic Processing: Keeping it Safe
Normally, these would be filtered out, but can [still] result in high prefiltration bioburden levels.”
Future GMP initiatives should focus on the minimization of human intervention in the aseptic …