Search results for "aav"

Article Insights and Strategies for Successful Development of Scalable AAV Processes: Part 2 of 2
Topics covered include: 1:00 – The upstream approach for AAV production, such as finding the balance between different parameters in the design of experiments to create a robust production proc…

Article Top Challenges to Overcome When Developing AAV Processes: Part 1 of 2
Topics covered include: 1:00 – Two main challenges for upstream AAV process development, including which development platform to use and scalability 3:09 – Parameters evaluated for AAV p…

Article How to Optimize and Scale Up AAV Production
In this article from a roundtable discussion, four experts from academia and industry met to discuss challenges in refining and scaling up AAV production pipelines to meet the increasing demand for …

Article Gene Therapies Push Viral Vector Production
By Feliza Mirasol  Several virus types have been studied for use as viral vectors in gene therapy, including adenovirus, lentivirus, retrovirus, and adeno-associated virus (AAV). Of these, AA…

Article A Look at the Affinity Chromatography Landscape
The greatest demand is for lentiviral and adeno-associated viral (AAV) vectors, with sourcing of lentiviral vectors becoming a bottleneck for gene and cell therapy manufacturing. Traditionally,…

Article Single-Use Technologies Prove Effective for Viral Vector Process Development
Notably for the manufacture of vectors based on adeno-associated virus (AAV), one of the most common vector types for gene therapy delivery and viral-vector vaccines, recent data have shown that stain…

Article Scaling Up Novel Therapies
Great improvements have been seen so far in delivering adeno-associated virus (AAV) vectors. These results demonstrate the inextricable link between clinical work and process development, said Kathy H…

Article Flexible Facilities for Viral Vector Manufacturing
Whereas for in-vivo gene therapies, using mostly AAV, the scale varies depending on the patient population, disease type, and route of injection, from a few 10 L up to 2000 L. For example, for Duchene…

Article Ensuring Viral Safety of Viral Vaccines and Vectors
In adeno-associated virus (AAV) processes, any replication-competent helper adenovirus must be inactivated and removed during downstream purification. AAV particles can resist heating at 52 ⁰C for 1…

Article The Challenge of Disruptive Technologies in Bioprocessing
Thermo Fisher Scientific has commercialized three POROS CaptureSelect AAV affinity resins to establish industrialized platforms for the purification of adeno-associated virus (AAV). The move is meant …

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