Search results for " transcription"

Article A Risk-Based Genetic Characterization Strategy for Recombinant CHO Cell Lines Used for Clinical and Commercial Applications
FHD=first human dose, FRD=first registration dose, PCR=polymerase chain reaction, qPCR=quantitative polymerase chain reaction, MCB=master cell bank, RT-PCR=reverse transcription polymerase chain react…

Article Regulatory Requirements for Safe and Efficient Biologic Drug Development
STEVE Click here to view more Industry Leader Q&As >> Steven Lynn, Executive Vice-President, Pharmaceuticals, Regulatory Compliance Associates, shares insight into regulatory require…

Article Genetic Vaccine Platforms Demonstrate Their Potential
In the case of mRNA vaccines, the transcription step is already completed, so the cells that take up the mRNA only need to transcribe the mRNA sequence into the protein-of-interest. Viral vector-based…

Article Increasing mRNA capabilities and capacity for growing market needs
The rapid development of innovative vaccines allowed for the pharmaceutical industry to deliver its first tools in the fight against the COVID-19 pandemic. READ FULL ARTICLE >>

Article Analytical Considerations for Successful Upstream Process Development with Spivey and Lane
Spivey and Lane Click here to view more Q&As >> Analytic considerations for upstream processing – covering Process Analytic Technology (PAT), time-savings versus off-line ana…

Article Enhancing Resins Addresses Purification Concerns
Because of this, large amounts of material are required for purifying the desired quantity of in-vitro transcription product. “Resins with higher binding capacities can address those challenges of the…

Article Insider Recommendations for Getting Started with Mechanistic Modeling of Chromatography
Insider Recommendations for Getting Started with Mechanistic Modeling of Chromatography Click here to view more Industry Leader Q&As >> Gunnar Malmquist, Senior Principal Scie…

Article Cell-free Expression Systems Pose Cell Culture Alternative
Cell-free expression is promising in preclinical applications, but still presents challenges to scale up for commercial production. Feliza Mirasol Among the challenges in upstrea…

Article Reimagining Affordable Biosimilars
Advances in preclinical development play a crucial role in reducing cost for developing biosimilars.  By Anurag S. Rathore, Narendra Chirmule, and Himanshu Malani  Drug development is …

Article Gene Therapies Push Viral Vector Production
The gene present in these vectors is generally flanked by a promoter sequence and a transcription terminator sequence to facilitate proper expression after it is incorporated into the host genome. Pla…

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