Search results for "downstream"

Article Downstream Processing Continues to Worry CMOs
Langer Downstream processing continues to be a significant pain point for contract manufacturing organizations (CMOs), and downstream-fueled bottlenecks don’t appear to show any signs of abating, …

Article Trends in Downstream Bioprocessing
Downstream processing (DSP) has seen significant challenges over the past few years. Improved upstream bioprocessing has created increasingly higher product titres and resulted in purification bottle …

Article QbD and PAT in Upstream and Downstream Processing
McKnight (Genentech): CQAs are defined for the product, not identified as part of upstream or downstream portions of the manufacturing process. There are key performance indicators (KPIs) that are def…

Article Addressing the Complex Nature of Downstream Processing with QbD
Challenges of QbD in downstream processing With the complex nature of biologics comes more complex quality concerns. Joey Studts, director late-stage ­downstream development in the bioprocessing de…

Article Using Single-Use Technologies in Downstream Processing
While the industry has used SUS in upstream processing for some time now, the use of single-use technologies is becoming popular in downstream processes as well. And it appears that the single-use tre…

Article Addressing the Challenges in Downstream Processing Today and Tomorrow
Increasing upstream titers and shrinking development timelines have posed several challenges to downstream process development of mAbs. Some of the major strategies and tools to address these challeng…

Article Single-Use for Downstream Chromatography: Benefit or Hindrance?
However, downstream single-use systems are still evolving, as vendors work to improve performance in critical areas. This article summarizes some of the benefits and the challenges of employing single…

Article Process Chromatography Selection for Downstream Processing Applications
Selecting the appropriate separation technology plays a big role in maximizing productivity in any downstream processing application. Some factors companies may consider when selecting a separation te…

Article Biopharma Moves to Integrated, Single-Use, Downstream Processing
A lack of single-use technologies The greatest barrier for adoption of single-use technology for downstream applications has been a lack of adequate technology, particularly in the sensor area, th…

Article Downstream Scale-up Purification of Influenza Virus Using ReadyToProcess Equipment
Total process time for the downstream purification was 3 days and the overall scale-up process resulted in production of influenza virus with the same yield and purity as obtained in the laboratory sc…

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