Search results for "plasmid"
Article
Enhancing Resins Addresses Purification Concerns
Deorkar also explains that plasmid DNA (pDNA) and recombinant adeno-associated viruses (rAAvs) are two other classes of biologic molecules that are of high interest for the biopharmaceutical industry …
Article
Working With Advanced Therapeutics: You Bring the Idea, We Bring the Map
Plasmids. mRNA. Oligos. Cell and gene therapies. Antibody variants. Vaccines. We all know these advanced therapies hold huge potential. But developing them isn’t straightforward, and fai…
Article
Top Process Development Trends for 2021 and a Look into 2022
…acellular vesicles and exosomes such as inherent therapeutic products and drug delivery vector; and plasmids, phages, and microbiome and microbiota. But many challenges are associated with the proces…
Article
Maximum Output Starts with Optimized Upstream Processing
Vaccine manufacturing in terms of capacity, according to Hitchcock, has largely been provided by CDMOs operating in the cell and gene therapy space for viral vector and plasmid DNA production. “Prior …
Article
Future Downstream Process Development Solutions for Advanced Therapies
Related Content
Q&As with Industry Leaders
mRNA manufacturing strategies
Manufacturing of viral vectors
Purification of plasmids
Oligonucleotide therapeutics
Article
Best Practices for Selecting a Top-Quality Cell Line
The plasmid ratio and medium are also important, Cai observes. “A balanced plasmid ratio usually has dramatic impact on some formats of bispecific antibody cell line development to minimize impurities…
Article
A Look at the Affinity Chromatography Landscape
He points to the use of conventional, non-porous particles in amino acids–DNA affinity chromatography for the purification of super-coiled plasmid DNA (sc pDNA) as an example. “Using amino acid affini…
Article
Fermentation for the Future
It is also useful for the production of cytokines, growth factors, and plasmid DNA. Reinisch also notes that media costs for microbial fermentation are lower, although media costs for cell culture hav…
Article
Novel Vaccine Technologies Meet the Need for Pandemic and Therapeutic Solutions
The DNA plasmids are manufactured using conventional fermentation technology (i.e., no eggs) that is scalable, is engineered for maximum expression in the host cells, and can be rapidly produced in la…
Article
Fundamentals of hydrophobic interaction chromatography
…* monoclonal antibodies (mAbs), bispecific mAbs and antibody-drug conjugates (ADC)
* mRNA
* plasmid
New to HIC? Browse this HIC resource library, containing our recently updated hand…