Search results for "scale-up"

Article Advanced Technologies Facilitate Scale-up and Technology Transfer
FDA’s focus on the need for updates is creating both opportunities and challenges for biologics manufacturers involved in the scale-up and transfer of production technologies. Single-use and modular t…

Article Scale-up of adherent Vero cells grown on Cytodex microcarrierrs using ReadyToProcess equipment
Our results show that the scale-up procedure using single-use WAVE Bioreactor systems is a fast and convenient option for virus production. To see an overview of a cell-based influenza vi…

Article High-throughput process development and scale-up of an intermediate purification step for recombinant insulin
The same system can also be used for initial scale-up to pilot scale in, for example, HiScale™ 16/40 columns. Further scale-up can be performed on AKTA avant 150 system and columns from the AxiChrom™ …

Article Downstream Scale-up Purification of Influenza Virus Using ReadyToProcess Equipment
Total process time for the downstream purification was 3 days and the overall scale-up process resulted in production of influenza virus with the same yield and purity as obtained in the laboratory sc…

Article Overview of a scale-up of a cell-based influenza virus production process using ReadyToProcess equipment
The white paper includes a brief discussion around modern vaccine processes, followed by a case study showing the scale-up of upstream and downstream processes for the production of a cell based live …

Article Faster scale-up of a two-step MAb process with AxiChrom™ columns and ReadyToProcess™ solutions
Scale-up needs to be robust, predictable, and the optimized conditions for removing aggregates, HCP, DNA, and viruses must be maintained or, preferably, improved. The addition of readyto-use solutions…

Article Factors Which Impact mAb Process Scale-Up
Fast Trak™ scientists discuss factors that can influence a successful scale-up outcome.

Article Multidimensional Scale-Up of a Monoclonal Antibody Capture Step, Using ÄKTA™ pilot 600
In this work, a multidimensional scale-up (change of both column diameter and bed height) of a mAb capture step, using the ÄKTA pilot 600 chromatography system, is demonstrated. Column volume per…

Article Process scale-up from HiScreen™ to HiScale™ columns
The two media used, MabSelect SuRe™ and Capto™ Q showed strong reproducibility and high yield (> 96%) during scale-up, demonstrating the excellent performance and consistency of HiScreen and HiScale c…

Article Scale-Up Model of a mAb Process from Microbioreactor to XDR-1000
A theoretical scale-up study was performed on a mAb process based on physical characterizations done on the Xcellerex XDR platform, from micro reactors up to large production-sized reactors. All inves…

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