Search results for " Xcellerex" in Articles / App Notes

Article Designing a 1.5 L Bench-Scale Model of a Perfusion Process
Establishing an appropriate model allows for higher throughput during simultaneous operation and monitoring of several cultures at different process conditions. In this article, we discus…

Article rAAV Production Using HEK293 Cell Line and Transfection Medium
  Improving the performance of a scalable AAV process in Xcellerex™ XDR-10 and XDR-200 bioreactor using HyClone™ peak expression medium. LEARN MORE >>

Article Scaling Up an E. coli Upstream Process for Plasmid DNA Production — from 2.5 to 160 L scale Fermenters
Read more >> This article summarizes the results of Escherichia coli growth performance for plasmid production in a 5 L glass fermentor, which was scaled up to 80 and 160 L scale in Xcellerex™ X…

Article Accelerating an Orphan Therapy to Market
Click here to learn more >> This case study shares the work of Cytiva’s Fast Trak Services team to help accelerate development of a process for cGMP production of material for toxicology studies.…

Article Perfusion N-1 – A Way to Improve the Fed-Batch Production Process
Click here to read more >> In this article, we show how the conventional N-1 seed train step was replaced by a high-density perfusion and how the production bioreactor can be seeded at a 10-fol…

Article Start-to-Finish Connected Manufacturing
That’s why we are demonstrating our mAb process that tested the performance of a new Xcellerex automatic perfusion system (APS) bioreactor, compared resin and fiber-based chromatography, and utilized …

Article Developing a Continuous Large-Scale Prefusion Cell Culture Process
Click here to read the article >> Perfusion processes enable continuous operation over extended periods of time by constantly providing fresh nutrients for the cells and simultaneously removing …

Article Improving Upstream Predictability
… Vermunt, and will soon introduce an automatic perfusion system that integrates into the company’s Xcellerex bioreactor platform to facilitate intensification during both N-1 and N stages. The compan…

Article Cell-Culture Advances Test Bioreactor Performance Models
Galliher, chief technical officer for upstream and founder of Xcellerex, a Cytiva business. “Successful modeling of bioreactors can reduce costs associated with engineering testing and engineering run…

Article Scale-Up Model of a mAb Process from Microbioreactor to XDR-1000
A theoretical scale-up study was performed on a mAb process based on physical characterizations done on the Xcellerex XDR platform, from micro reactors up to large production-sized reactors. All inves…

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