Search results for " adenovirus"

Article Developing an Efficient Adenovirus Downstream Purification Process
This application note describes the development of downstream chromatography steps for purification of adenovirus from HEK293 cell culture harvest. To read the application note click her…

Article Achieving Efficient Adenovirus Upstream Production
This application note describes the production of adenovirus in HEK293 suspension cells in a bioreactor system. Triplicate cultures demonstrate a reproducible and robust batch production of adenovirus

Article Case Study: Process for Production of Oncolytic Adenovirus
Here, we present a case study from a biomanufacturer developing a process for adenovirus oncolytic adenovirus production. The case study describes a process from upstream cell culture to downstream pu…

Article Optimization of Adenovirus Midstream Purification Steps
In this application note, studies of midstream purification steps in an adenovirus production process is performed. Based on the results, suggestions for the choice of consumables and conditions for v…

Article Evaluation of HEK293 Cell Growth and Adenovirus Productivity in HyClone™ CDM4HEK293 Medium
HEK293 cells are susceptible to infection by adenovirus, one of the most frequently used viral vectors in the development of therapeutic vaccines and vaccines against infectious diseases. This applica…

Poster Adenovirus production in a single-use stirring tank bioreactor system
In this work we demonstrate an efficient process for adenovirus production in a single-use stirred-tank bioreactor, using HEK293 cells adapted for suspension culture. Human adenovirus 5 expressing gre…

Article Evaluation of Hek293 Cell Growth and Adenovirus Productivity in HyClone CDM4HEK293 Medium
This application note demonstrates growth and adenovirus productivity of HEK293 cells and explores the key factors involved in the optimization of cell culture performance and scalability. Clic…

Poster A Scalable Adenovirus Production Process, from Cell Culture to Purified Bulk
Adenovirus (AdV) vectors are commonly used in cancer gene therapy trials and evaluated for use in vaccines for various diseases. In this study, we have combined technical evaluation of process steps a…

Poster A Scalable Adenovirus Production Process
To meet these needs, a process for adenovirus production, from upstream cell culture to downstream purification, using modern tools and technologies was developed. The novel process is easily sc…

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