Search results for " tangential flow filtration"

Article Robust and Reliable Filtration
Automate your tangential flow filtration (TFF) process for consistent performance, significant time savings, and extensive data recording. Discover GE’s single-use automated filtration solution, …

Article Upcoming Technologies to Facilitate More Efficient Biologics Manufacturing
One of the commonly used technologies for primary separation after fermentation is tangential flow filtration (TFF).7 TFF processes have traditionally used cassettes or hollow fiber formats. Typically…

Article Bioterminology: A Guide to the Biopharmaceutical Lexicon
Bioterminology: A Guide to the Biopharmaceutical Lexicon This lexicon was generated by the editors of BioPharm International magazine. Please feel free to email your suggestions for terms that s…

Article Challenges in Cell Harvesting Prompt Enhancements
In cell harvesting, depth filters can be used in conjunction with centrifugation or another primary separator, such as tangential flow filtration, as well as being applied directly to whole cell broth…

Article Purification Strategies to Process 5 g/L Titers of Monoclonal Antibodies
After the third chromatography step, ultrafiltration–diafiltration is performed using tangential flow filtration (TFF) for final product formulation. Potential volume bottlenecks caused by increase…

Article Downstream Processing for Cell-Based Therapies
By Qasim A. Rafiq, Fernanda Masri With increasing numbers of advanced therapies—including cell and gene therapies—entering early- and late-stage clinical development, significant focus has been …

Article Achieving Process Balance with Perfusion Bioreactors
Advances in single-use technologies, sensors, and cell retention systems facilitate processes designed for the long run. By Cynthia A. Challener  MG/Stock.Adobe.com …

Article Continuous Processing for the Production of Biopharmaceuticals
The authors review the technologies that may help bioprocessing become a truly continuous operation and present case studies that could contribute to the integration of upstream and downstream platf…

Article Tools for Continuous Bioprocessing Development
For example, perfusion process development experiments (21) using a 4-L working-volume Wave bag and alternating tangential flow (ATF) or tangential flow filtration (TFF) cell-retention filter, consume…

Article Concentration and Buffer Exchange Using the Automated, Single-Use ÄKTA™ readyflux System
The process was performed according to set specifications for a tangential flow filtration (TFF) process, with the added benefits of the single‑use technology and consistency through automation. …

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